Forecast Ledgerinterventional psychiatry and psychedelic medicineQuoted, dated predictions scored against public outcomes under one written method. Every score links to the words, the rule and the evidence.

True · Brier 0.09

Rules 1.1.0 · as of 14 Sep 2026

Quote

“And if you look at Spravato's numbers today you see they are now growing substantially and anticipated to shortly hit "blockbuster" status.”
· Christian Angermayer on X: atai (Nasdaq: ATAI) went public almost exactly 3 years ago · tweet

Same tweet; he uses J&J's Spravato as the precedent for a psychedelic-type drug reaching blockbuster ($1bn) sales, saying it will happen shortly.

Intake

EventA proposition written from a template on the asset, with a resolution criterion and a named public source, before the outcome is looked up. The same event resolves every person's items on it. Method ›
Spravato annual sales at or above US$1 billion
AreaOne of five topic classes: regulatory decisions, clinical trial outcomes, company and market outcomes, payer and policy, practice adoption. Every event has one area. Method ›
Company and market outcomes
DeadlineThe date by which the event must happen for the item to be true. It comes only from the person's words through the anchor table. Method ›
None stated · undated panelItems with no deadline in the person's words, scored on a uniform 24-month window from the statement date. Part of the headline panel since rules 1.1.0; also shown on its own. Method ›, 24-month window to 24 Jun 2026
Probability
0.70 LexiconThe fixed five-bin table that turns a phrase into a probability. The strongest phrase in the claim sentence decides; coders never read tone. Method › · binOne of five lexicon steps: A 'will' 0.90, B 'probably' 0.70, C 'may' 0.50, D 'unlikely' 0.30, E 'never' 0.10. A stated number goes to the nearest bin for calibration only. Method › B · “anticipated to shortly hit "blockbuster" status”
Base rateThe probability a published external study gives an event of that class and stage, fixed at intake. Halved when the item window is shorter than the class median time to decision. Never learned from the ledger's own items. Method ›
None in the table
Tags
retrospective
Coder BCohen's kappa: agreement between two coders beyond chance, from -1 to 1. Reported for admit, event, deadline, bin and asserts from the second-coder match test. Method ›
admittedA statement that passed intake: sincere, the person's own claim, forward-looking, inside the five areas, and not excluded by a reason code. Only admitted statements become items. Method › · event E-0092 · deadline none · bin B
Registry entry

Worldwide net sales of Spravato (esketamine nasal spray) reach at or above US$1 billion in a calendar year, per Johnson & Johnson's reported product sales.

Resolved on the named data series only: worldwide net trade sales of Spravato (esketamine nasal spray) in Johnson & Johnson's product-sales tables in its periodic reports on SEC EDGAR (Form 10-K and 10-Q) and the sales exhibits of its quarterly earnings releases (Form 8-K). TRUE on the date of the first Johnson & Johnson report that shows Spravato worldwide net sales at or above US$1 billion for a calendar year. 'Blockbuster' in the forecaster's words is read as US$1 billion of annual sales, the standard industry meaning, so the event resolves as binary at US$1 billion with no band. FALSE at the deadline when no completed calendar year has reached US$1 billion in the reported series. Unresolvable if the series stops and no figure has published 12 months after the deadline. Realized values are stored, not scored.

Resolution source: Johnson & Johnson product sales tables in its Form 10-K, Form 10-Q and earnings-release exhibits on SEC EDGAR

Readings: '"blockbuster" status' = annual sales of US$1 billion, the standard industry meaning; the forecaster puts the word in quotation marks and gives no other number.; 'shortly' is not a deadline; the item goes to the undated panel.; The passive 'anticipated to' is adopted by the forecaster: he uses the Spravato trajectory as the precedent for his own thesis in the same tweet.

How to read
The event, criterion and deadline were written at intake, before the outcome1 if the registry event happened on or before the item's deadline, 0 if it did not. Written by a resolver who never sees p. Method › was looked up. Coder B coded the statement independently.

Coder A

Resolution

State
True
Effective deadlineAn item enters the score only when its deadline has passed and the outcome is true or false. A claim already known true still waits for its deadline. Method ›
24 Jun 2026
Outcome1 if the registry event happened on or before the item's deadline, 0 if it did not. Written by a resolver who never sees p. Method ›
occurred on 22 Jan 2025 · checked through 14 Sep 2026
Resolver note
Spravato passed US$1 billion in calendar year 2024. The first Johnson & Johnson report showing it is the Q4 and full-year 2024 earnings release, Form 8-K Exhibit 99.2 filed 2025-01-22, which gives Spravato worldwide net trade sales of $1,077 million for 2024 (US $929M, international $148M), up 56.4% on 2023. The FY2024 Form 10-K filed 2025-02-13 carries the same product-sales tables. The FY2025 release of 2026-01-21 shows $1,696 million, confirming the series. Date taken as the first reporting date, 2025-01-22; realized value is the 2024 figure.
BrierThe squared gap between a probability and the outcome, (p - o)^2. 0 is perfect, 0.25 is the constant coin flip, 1 is confidently wrong. Lower is better. Method ›
0.09 = (0.70 − 1)²
Adversarial recheck

upheld (date): Case for an earlier date: Spravato sales were running above US$250 million a quarter through 2024, so a rolling four-quarter total crossed US$1 billion inside 2024, and the Q3 2024 Form 10-Q would then be the first report showing it. The criterion blocks this: it asks for Spravato worldwide net sales at or above US$1 billion 'for a calendar year' in the named series, and no J&J report before the 2024 full-year figures states one. The Form 8-K Exhibit 99.2 supplementary sales data filed 2025-01-22 gives SPRAVATO worldwide US$1,077 million for full-year 2024 against US$689 million for 2023, up 56.4%. 2023 is below the threshold, so 2024 is the first qualifying calendar year and 2025-01-22 the first report of it. The FY2024 Form 10-K of 2025-02-13 repeats it; FY2025 at US$1,696 million confirms the series. State, date and realized value stand.

How to read
State at window close; the outcome comes from the registry, the score from the rule.

Registry

Timeline

1 claim against 40 events in the field.

saiddueevent
12 Aug 2024 · Neuronetics / Greenbrook TMS: Neuronetics agrees an all-stock merger with Greenbrook TMS, the largest US TMS c13 Aug 2024 · MindMed: MindMed closes a $75M public offering, bringing 2024 gross equity raises to abou15 Aug 2024 · Lykos Therapeutics: Lykos cuts about 75% of its roughly 100 staff after the CRL and retractions; fou5 Sep 2024 · Lykos Therapeutics: Lykos CEO Amy Emerson steps down; COO Michael Mullette becomes interim CEO and D31 Oct 2024 · Compass Pathways: Compass delays COMP005 topline to Q2 2025 and COMP006 data to after the 26-week 15 Nov 2024 · Numinus Wellness / Stella: Numinus agrees to sell its five Utah wellness clinics to Stella MSO and pivots t9 Dec 2024 · Neuronetics / Greenbrook TMS: Neuronetics completes the Greenbrook TMS merger, becoming a vertically integrate17 Dec 2024 · Numinus Wellness / Stella: Numinus closes the sale of its US clinics to Stella and launches a data-sharing 10 Jan 2025 · Lykos Therapeutics / Antonio Gracias: Billionaire investor Antonio Gracias moves to take control of Lykos with about $13 Jan 2025 · Johnson & Johnson / Intra-Cellular Therapies: J&J agrees to acquire Intra-Cellular Therapies (Caplyta) in its largest neurosci15 Jan 2025 · Lykos Therapeutics: Five Lykos board directors depart as the company seeks new funding after the FDA22 Jan 2025 · Johnson & Johnson (Spravato): J&J Q4 2024 results show Spravato crossed $1B in annual sales for the first time30 May 2025 · Lykos Therapeutics: Lykos completes the first close of a Series B co-led by the Gracias Family Found2 Jun 2025 · atai Life Sciences / Beckley Psytech: atai agrees an all-share combination with Beckley Psytech, contingent on BPL-00316 Jun 2025 · Supernus Pharmaceuticals / Sage Therapeutics: Supernus agrees to acquire Sage Therapeutics (Zurzuvae) after Sage rebuffed Biog23 Jun 2025 · Compass Pathways: Compass shares fall sharply as investors judge the 3.6-point COMP005 effect size30 Jun 2025 · Cybin: Cybin announces a financing of up to $500M in convertible debentures to fund its20 Aug 2025 · Lykos Therapeutics: Lykos names former Point72 capital markets head Nick McEntire as president under28 Aug 2025 · Lykos Therapeutics / Resilient Pharmaceuticals: Lykos Therapeutics rebrands as Resilient Pharmaceuticals following the Gracias-l22 Oct 2025 · Mindbloom: A wrongful-death lawsuit is filed against at-home ketamine provider Mindbloom ov31 Oct 2025 · MindMed: MindMed closes an upsized underwritten public offering after positive phase 3 pl5 Nov 2025 · AtaiBeckley: atai and Beckley Psytech complete their combination to form AtaiBeckley; a $150M19 Nov 2025 · Done Global: A federal jury convicts Done founder Ruthia He and clinical president David Brod17 Dec 2025 · Done Global: A federal grand jury indicts Done Global itself over the alleged $100M Adderall 5 Jan 2026 · Cybin / Helus Pharma: Cybin rebrands as Helus Pharma and moves its US listing to Nasdaq under ticker H12 Jan 2026 · MindMed / Definium Therapeutics: MindMed rebrands as Definium Therapeutics (Nasdaq: DFTX from Jan 15) and guides 21 Jan 2026 · Johnson & Johnson (Spravato): J&J full-year 2025 results show Spravato sales of about $1.7B, with Q4 2025 up 618 Feb 2026 · Compass Pathways: Compass prices a $150M public offering the day after COMP006 topline; with warra1 Mar 2026 · Alto Neuroscience: Alto closes a $120M private placement led by Commodore Capital at $20 per share,17 Mar 2026 · Neuronetics: Neuronetics appoints Dan Reuvers as CEO as 2025 revenue nearly doubles after the7 Apr 2026 · Neuronetics: Neuronetics' top shareholder says the company has 'chronically underperformed' a29 Apr 2026 · GH Research: GH Research prices a $117.5M underwritten offering at $18 per share to fund the 13 May 2026 · Compass Pathways: Compass Q1 2026 update: rolling NDA sections already submitted, final submission25 Jun 2026 · Definium Therapeutics: Definium closes an upsized $805M public offering at $34 per share three days aft25 Jun 2026 · Helus Pharma: Helus completes a $50M underwritten offering, lifting cash to about $207M ahead 8 Jul 2026 · Done Global: Done founder Ruthia He is sentenced to 72 months in prison and fined $90M for th15 Jul 2026 · Johnson & Johnson (Spravato): J&J Q2 2026 results show Spravato sales of $584M, up 25% quarter over quarter an16 Jul 2026 · Eli Lilly / AtaiBeckley: Lilly agrees to acquire AtaiBeckley for $6.75 per share cash plus a CVR of up to3 Aug 2026 · Helus Pharma: Helus Pharma appoints Michael Halstead as chief executive officer ahead of its p11 Sep 2026 · Eli Lilly / AtaiBeckley: Eli Lilly completes its acquisition of AtaiBeckley, taking BPL-003 and VLS-01 inELI LILLY / ATAIBECKLEY: ELI LILLY COMPLETES ITS ACQUISITION OF ATAIBECKLEY, TAKING BPL-003 AND VLS-01 INSPRAVATO ANNUAL S…Spravato annual sales at or above US$1 billion · stated 24 Jun 2024Spravato annual sales at or above US$1 billion · restated 24 Jun 2024 · p 70%Spravato annual sales at or above US$1 billion · hit 22 Jan 202570%TODAY20252026

Company and market outcomes